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1

Modulating the Strength and Threshold of NOTCH Oncogenic Signals by mir-181a-1/b-1

Fragoso, Rita, Mao, Tin, Wang, Song, Schaffert, Steven, Gong, Xue, Yue, Sibiao, Luong, Richard, Min, Hyeyoung, Yashiro-Ohtani, Yumi, Davis, Mark, Pear, Warren, Chen, Chang-Zheng, Grimes, H. Leighton

Journal:

Year:

2012

Language:

english

File:

PDF, 3.36 MB

english, 2012

2

Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation

Zhou, Yile, Yan, Xiaomei, Feng, Xiaomin, Bu, Jiachen, Dong, Yunzhu, Lin, Peipei, Hayashi, Yoshihiro, Huang, Rui, Olsson, Andre, Andreassen, Paul R., Grimes, H. Leighton, Wang, Qian-fei, Cheng, Tao, Xi

Journal:

Year:

2018

Language:

english

File:

PDF, 9.48 MB

english, 2018

3

A guide to choosing fluorescent protein combinations for flow cytometric analysis based on spectral overlap

Kleeman, Benjamin, Olsson, Andre, Newkold, Tess, Kofron, Matt, DeLay, Monica, Hildeman, David, Grimes, H. Leighton

Journal:

Cytometry Part A

Year:

2018

Language:

english

File:

PDF, 557 KB

english, 2018

4

Cooperation between RUNX1-ETO9a and Novel Transcriptional Partner KLF6 in Upregulation of Alox5 in Acute Myeloid Leukemia

DeKelver, Russell C., Lewin, Benjamin, Lam, Kentson, Komeno, Yukiko, Yan, Ming, Rundle, Chandler, Lo, Miao-Chia, Zhang, Dong-Er, Grimes, H. Leighton

Journal:

Year:

2013

Language:

english

File:

PDF, 1.64 MB

english, 2013

5

Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes

Yáñez, Alberto, Coetzee, Simon, Olsson, Andre, Muench, David, Berman, Benjamin, Hazelett, Dennis, Salomonis, Nathan, Grimes, H. Leighton, Goodridge, Helen

Journal:

Experimental Hematology

Year:

2018

Language:

english

File:

PDF, 59 KB

english, 2018

6

The Human Cell Atlas Bone Marrow Single-Cell Interactive Web Portal

Hay, Stuart, Ferchen, Kyle, Chetal, Kashish, Grimes, H. Leighton, Salomonis, Nathan

Journal:

Experimental Hematology

Year:

2018

Language:

english

File:

PDF, 811 KB

english, 2018

7

CRISPR editing of sftb-1/SF3B1 in Caenorhabditis elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing

Serrat, Xènia, Kukhtar, Dmytro, Cornes, Eric, Esteve-Codina, Anna, Benlloch, Helena, Cecere, Germano, Cerón, Julián, Grimes, H. Leighton

Journal:

Year:

2019

Language:

english

File:

PDF, 7.30 MB

english, 2019

8

Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism

Laura McGhee, Josh Bryan, Liza Elliott, H. Leighton Grimes, Avedis Kazanjian, J. Nathan Davis, Shari Meyers

Journal:

Journal of Cellular Biochemistry

Year:

2003

Language:

english

File:

PDF, 411 KB

english, 2003

9

MicroRNAs in the midst of myeloid signal transduction

Sara L. Stoffers, Sara E. Meyer, H. Leighton Grimes

Journal:

Journal of Cellular Physiology

Year:

2012

Language:

english

File:

PDF, 221 KB

english, 2012

10

The growth factor independence-1 transcription factor: New functions and new insights

Avedis Kazanjian, Eleanore A. Gross, H. Leighton Grimes

Journal:

Critical Reviews in Oncology/Hematology

Year:

2006

Language:

english

File:

PDF, 277 KB

english, 2006

11

CHEMICAL AND SENSORY ANALYSIS OF THE PURPLE-HINGE ROCK SCALLOP Hinnites multirugosus GALE

C. F. PHLEGER, R. B. HOLTZ, P. W. GRIMES, D. L. LEIGHTON, F. JACOBSEN

Journal:

Journal of Food Science

Year:

1978

Language:

english

File:

PDF, 565 KB

english, 1978

12

Loss of GFI1 impairs pulmonary neuroendorine cell proliferation, but the neuroendocrine phenotype has limited impact on post-naphthalene airway repair

Linnoila, R Ilona, Jensen-Taubman, Sandra, Kazanjian, Avedis, Grimes, H Leighton

Journal:

Laboratory Investigation

Year:

2007

Language:

english

File:

PDF, 35.16 MB

english, 2007

13

Graft facilitating cells are derived from hematopoietic stem cells and functionally require CD3, but are distinct from T lymphocytes

H. Leighton Grimes, Carrie L. Schanie, Yiming Huang, Daniel Cramer, Francine Rezzoug, Isabelle Fugier-Vivier, Suzanne T. Ildstad

Journal:

Experimental Hematology

Year:

2004

Language:

english

File:

PDF, 772 KB

english, 2004

14

MIR-23A microRNA cluster inhibits B-cell development

Kimi Y. Kong, Kristin S. Owens, Jason H. Rogers, Jason Mullenix, Chinavenmeni S. Velu, H. Leighton Grimes, Richard Dahl

Journal:

Experimental Hematology

Year:

2010

Language:

english

File:

PDF, 1.84 MB

english, 2010

15

Intranuclear staining of proteins in heterogeneous cell populations and verification of nuclear localization by flow cytometric analysis

Loretta L. Doan, Michael K. Tanner, H.Leighton Grimes

Journal:

Journal of Immunological Methods

Year:

2003

Language:

english

File:

PDF, 701 KB

english, 2003

16

Hox and Senseless Antagonism Functions as a Molecular Switch to Regulate EGF Secretion in the Drosophila PNS

David Li-Kroeger, Lorraine M. Witt, H. Leighton Grimes, Tiffany A. Cook, Brian Gebelein

Journal:

Developmental Cell

Year:

2008

Language:

english

File:

PDF, 1.76 MB

english, 2008

17

Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines: A Novel Mechanism for Maximizing IL-7-Dependent T Cell Survival

Jung-Hyun Park, Qing Yu, Batu Erman, Jacob S. Appelbaum, Diego Montoya-Durango, H.Leighton Grimes, Alfred Singer

Journal:

Year:

2004

Language:

english

File:

PDF, 887 KB

english, 2004

18

Mutations in Growth Factor Independent-1 Associated with Human Neutropenia Block Murine Granulopoiesis through Colony Stimulating Factor-1

Adrian Zarebski, Chinavenmeni S. Velu, Avinash M. Baktula, Tristan Bourdeau, Shane R. Horman, Sudeep Basu, Salvatore J. Bertolone, Marshal Horwitz, David A. Hildeman, John O. Trent, H. Leighton Grimes

Journal:

Year:

2008

Language:

english

File:

PDF, 1.19 MB

english, 2008

19

Krüppel-Like Factor 5 Is Not Required for K-RasG12D Lung Tumorigenesis, but Represses ABCG2 Expression and Is Associated with Better Disease-Specific Survival

Sara E. Meyer, Jason R. Hasenstein, Avinash Baktula, Chinavenmani S. Velu, Yan Xu, Huajing Wan, Jeffrey A. Whitsett, C. Blake Gilks, H. Leighton Grimes

Journal:

The American Journal of Pathology

Year:

2010

Language:

english

File:

PDF, 1.06 MB

english, 2010

20

ELANE Mutations in Cyclic and Severe Congenital Neutropenia

Horwitz, Marshall S., Corey, Seth J., Grimes, H. Leighton, Tidwell, Timothy

Journal:

Hematology/Oncology Clinics of North America

Year:

2013

Language:

english

File:

PDF, 491 KB

english, 2013

21

Expression of the IGF system in primary and immortalized porcine ovarian granulosa cells

Leighton, John K., Grimes, Randall W., Canning, Sandra, Hammond, James M.

Journal:

Molecular and Cellular Endocrinology

Year:

1993

Language:

english

File:

PDF, 1.08 MB

english, 1993

22

IGF-binding proteins are differentially regulated in an ovarian granulosa cell line

Leighton, John K., Grimes, Randall W., Canning, Sandra F., Hammond, James M.

Journal:

Molecular and Cellular Endocrinology

Year:

1994

Language:

english

File:

PDF, 693 KB

english, 1994

23

The Gfi-1 Protooncoprotein Represses Bax Expression and Inhibits T-Cell Death

H. Leighton Grimes, C. Blake Gilks, Tung O. Chan, Susan Porter and Philip N. Tsichlis

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.38 MB

english, 1996

24

Transduction of Interleukin-2 Antiapoptotic and Proliferative Signals via Akt Protein Kinase

Naheed N. Ahmed, H. Leighton Grimes, Alfonso Bellacosa, Tung O. Chan and Philip N. Tsichlis

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.61 MB

english, 1997

25

Single cell transcriptome-based dissection of lineage fate decisions in myelopoiesis

Grimes, H. Leighton, Olsson, Andre, Aronow, Bruce, Chaudhri, Virendra, Dexheimer, Phillip, Singh, Harinder

Journal:

Experimental Hematology

Year:

2014

Language:

english

File:

PDF, 51 KB

english, 2014

26

Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein

Cumaraswamy, Abbarna A., Lewis, Andrew M., Geletu, Mulu, Todic, Aleksandra, Diaz, Diego B., Cheng, Xin Ran, Brown, Carla E., Laister, Rob C., Muench, David, Kerman, Kagan, Grimes, H. Leighton, Minden,

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 337 KB

english, 2014

27

Government & education news

Leighton, Patricia, Bastin, Nigel A., Grimes, Richard

Journal:

The Law Teacher

Year:

1994

Language:

english

File:

PDF, 986 KB

english, 1994

28

Past Visits Present: TCF/LEFs Partner with ATFs for β-Catenin–Independent Activity

Sprowl, Stephanie, Waterman, Marian L., Grimes, H. Leighton

Journal:

Year:

2013

Language:

english

File:

PDF, 233 KB

english, 2013

29

Ago1 Interacts with RNA Polymerase II and Binds to the Promoters of Actively Transcribed Genes in Human Cancer Cells

Huang, Vera, Zheng, Jiashun, Qi, Zhongxia, Wang, Ji, Place, Robert F., Yu, Jingwei, Li, Hao, Li, Long-Cheng, Grimes, H. Leighton

Journal:

Year:

2013

Language:

english

File:

PDF, 4.20 MB

english, 2013

30

Unmet Expectations: miR-34 Plays No Role in p53-Mediated Tumor Suppression In Vivo

Jain, Abhinav K, Barton, Michelle Craig, Grimes, H. Leighton

Journal:

Year:

2012

Language:

english

File:

PDF, 83 KB

english, 2012

31

The Long Path from QTL to Gene

Drinkwater, Norman R., Gould, Michael N., Grimes, H. Leighton

Journal:

Year:

2012

Language:

english

File:

PDF, 535 KB

english, 2012

32

Acquisition Order of Ras and p53 Gene Alterations Defines Distinct Adrenocortical Tumor Phenotypes

Herbet, Maryline, Salomon, Aude, Feige, Jean-Jacques, Thomas, Michaël, Grimes, H. Leighton

Journal:

Year:

2012

Language:

english

File:

PDF, 10.30 MB

english, 2012

33

Ataxin1L Is a Regulator of HSC Function Highlighting the Utility of Cross-Tissue Comparisons for Gene Discovery

Kahle, Juliette J., Souroullas, George P., Yu, Peng, Zohren, Fabian, Lee, Yoontae, Shaw, Chad A., Zoghbi, Huda Y., Goodell, Margaret A., Grimes, H. Leighton

Journal:

Year:

2013

Language:

english

File:

PDF, 2.67 MB

english, 2013

34

The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis

Bottardi, Stefania, Mavoungou, Lionel, Pak, Helen, Daou, Salima, Bourgoin, Vincent, Lakehal, Yahia A., Affar, El Bachir, Milot, Eric, Grimes, H. Leighton

Journal:

Year:

2014

Language:

english

File:

PDF, 1.54 MB

english, 2014

35

Cadm1 Is a Metastasis Susceptibility Gene That Suppresses Metastasis by Modifying Tumor Interaction with the Cell-Mediated Immunity

Faraji, Farhoud, Pang, Yanli, Walker, Renard C., Nieves Borges, Rosan, Yang, Li, Hunter, Kent W., Grimes, H. Leighton

Journal:

Year:

2012

Language:

english

File:

PDF, 2.36 MB

english, 2012

36

Intact p53-Dependent Responses in miR-34–Deficient Mice

Concepcion, Carla P., Han, Yoon-Chi, Mu, Ping, Bonetti, Ciro, Yao, Evelyn, D'Andrea, Aleco, Vidigal, Joana A., Maughan, William P., Ogrodowski, Paul, Ventura, Andrea, Grimes, H. Leighton

Journal:

Year:

2012

Language:

english

File:

PDF, 1.66 MB

english, 2012

37

Synergistic Interaction of Rnf8 and p53 in the Protection against Genomic Instability and Tumorigenesis

Halaby, Marie-Jo, Hakem, Anne, Li, Li, El Ghamrasni, Samah, Venkatesan, Shriram, Hande, Prakash M., Sanchez, Otto, Hakem, Razqallah, Grimes, H. Leighton

Journal:

Year:

2013

Language:

english

File:

PDF, 5.20 MB

english, 2013

38

Growth factor independent-1 Maintains Notch1-Dependent Transcriptional Programming of Lymphoid Precursors

Phelan, James D., Saba, Ingrid, Zeng, Hui, Kosan, Christian, Messer, Malynda S., Olsson, H. Andre, Fraszczak, Jennifer, Hildeman, David A., Aronow, Bruce J., Möröy, Tarik, Grimes, H. Leighton, Goodell

Journal:

Year:

2013

Language:

english

File:

PDF, 2.03 MB

english, 2013

39

Controlling Pre-leukemic Thymocyte Self-Renewal

Goossens, Steven, Van Vlierberghe, Pieter, Grimes, H. Leighton

Journal:

Year:

2014

Language:

english

File:

PDF, 370 KB

english, 2014

40

C- ski cDNAs are encoded by eight exons, six of which are closely linked within the chicken genome

Grimes, H.Leighton, Szente, Brian E., Goodenow, Maureen M.

Journal:

Nucleic Acids Research

Year:

1992

Language:

english

File:

PDF, 577 KB

english, 1992

41

Transcriptional Control of Stem and Progenitor Potential

Muench, David E., Grimes, H. Leighton

Journal:

Current Stem Cell Reports

Year:

2015

Language:

english

File:

PDF, 567 KB

english, 2015

42

Myeloid Malignancies with Chromosome 5q Deletions Acquire a Dependency on an Intrachromosomal NF-κB Gene Network

Fang, Jing, Barker, Brenden, Bolanos, Lyndsey, Liu, Xiaona, Jerez, Andres, Makishima, Hideki, Christie, Susanne, Chen, Xiaoting, Rao, Dinesh S., Grimes, H. Leighton, Komurov, Kakajan, Weirauch, Matthe

Journal:

Year:

2014

Language:

english

File:

PDF, 3.23 MB

english, 2014

43

Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis

Fukun Guo, David Hildeman, Pulak Tripathi, Chinavenmeni S. Velu, H. Leighton Grimes, Yi Zheng and N. Avrion Mitchison

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.46 MB

english, 2010

44

Graft tolerance and acceptance in xenotransplantation

Grimes, H. Leighton, Kaufman, Christina L., Rivoli, Rachel, Ildstad, Suzanne T.

Journal:

Current Opinion in Organ Transplantation

Year:

2002

Language:

english

File:

PDF, 257 KB

english, 2002

45

A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes

Fang, Jing, Liu, Xiaona, Bolanos, Lyndsey, Barker, Brenden, Rigolino, Carmela, Cortelezzi, Agostino, Oliva, Esther N, Cuzzola, Maria, Grimes, H Leighton, Fontanillo, Celia, Komurov, Kakajan, MacBeth,

Journal:

Nature Medicine

Year:

2016

Language:

english

File:

PDF, 1.25 MB

english, 2016

46

The Gfi-1B Proto-Oncoprotein Represses p21 WAF1 and Inhibits Myeloid Cell Differentiation

Tong, Betty, Grimes, H. Leighton, Yang, Tong-Yuan, Bear, Susan E., Qin, Zhihai, Du, Keyong, El-Deiry, Wafik S., Tsichlis, Philip N.

Journal:

Molecular and Cellular Biology

Year:

1998

Language:

english

File:

PDF, 1.53 MB

english, 1998

47

Gfi1–cells and circuits: unraveling transcriptional networks of development and disease

Phelan, James D, Shroyer, Noah F, Cook, Tiffany, Gebelein, Brian, Grimes, H Leighton

Journal:

Current Opinion in Hematology

Year:

2010

Language:

english

File:

PDF, 273 KB

english, 2010

48

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

Olsson, Andre, Venkatasubramanian, Meenakshi, Chaudhri, Viren K., Aronow, Bruce J., Salomonis, Nathan, Singh, Harinder, Grimes, H. Leighton

Journal:

Year:

2016

Language:

english

File:

PDF, 13.38 MB

english, 2016

49

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

Olsson, Andre, Venkatasubramanian, Meenakshi, Chaudhri, Viren K., Aronow, Bruce J., Salomonis, Nathan, Singh, Harinder, Grimes, H. Leighton

Journal:

Experimental Hematology

Year:

2016

Language:

english

File:

PDF, 34 KB

english, 2016

50

KLF5 deficiency is required for B-cell lymphoid progenitor leukemogenesis to promote glutathione biosynthesis and prevent oxidative stress

Cancelas, Jose, Zhang, Cuiping, D'Alessandro, Angelo, Wellendorf, Ashley, Mohmoud, Fatima, Dasgupta, Biplab, Whitsett, Jeffrey, Grimes, H Leighton

Journal:

Experimental Hematology

Year:

2016

Language:

english

File:

PDF, 42 KB

english, 2016